FWIW, when I work up loads for my rifles I'll start with 2 or 3 differetnt bullet weights. I always make a varmint load and a deer load so I will use the lightest bullet I can find for the caliber and a heavier bullet for deer. Start with published data and make about 5 or 6 loads with different powders and a single bullet weight/style. I'll shoot them in 3 shot groups at 50 yards then 100 yards. I'll tweak each load after the initial testing if it looks promising. Usually I can get down to 2 or 3 loads that will fill the bill. Then I'll play around with seating depth using a seating gauge to find exactly how far I can go with my bullet until I contact the grooves/lands. It's not a complicated process and it's great to do in the winter when I don't have 50 other things to take care of. Let's just say this process works well enough that I can pick up any of my rifles and have confidence in their ability to make things assume room temperature.