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I had a 450-400 3 1/4" H&H Royal grade sidelock, and it was a brutal beast using Kynoch ammo. I tried reloading it and the only loads that would shoot to the same point of impact were equally punishing. Since the only cases available used Berdan primers, and the Kynoch ammo was available, I gave up trying to reload it, and just shot Kynoch. The gun was overpowered for virtually any North American game that I hunted. I guess it would be good enough medicine for Grissly.
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