Bullet placement is everything no matter what your shooting at. I folded up a buff with a 400gr Swift A Frame from a 416 Taylor but made a poor shot on a Zebra with the same gun and we had a chase on our hands for a half mile or so.
I have a Ruger #1 450-400 NE that I'm trying to turn into a deer rifle 
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There is no hunting like the hunting of man, and those who have hunted armed men long enough and liked it, never care for anything else thereafter...Earnest Hemingway
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