I'm in Dean's corner on this...use #6's in your first barrel. I had a friend body shoot a nice tom with 2 1/4 oz of heavy shot #4's he broke one wing and opposite leg...had to go get the Lab and when we returned couple hours latter there was quit a row before the tom was subdued...made for one of my favorite memories of my now deceased buddy though.
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" We give a dog time we can spare, space we can spare and love we can spare. And in return, our dog gives us their all. It's the best darn deal man has ever made." M. Acklam
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