Todd, I have found that each slug gun is a world unto itself and some are best with a certain brand of slug and not as good with another. Some shoot Remington best and some shoot other brands best. The only way to tell is to shoot at paper to find out which loading gives the best results for a particular gun. I have a friend whose gun shoots the Brennekes best and another whose gun sprays them. The same is true for rifles. I used to tailor my handloads for specific guns. Some liked Hornady bullets best and some liked other brands. As a rule, I have found that hot loads grouped less effectively than moderate loads. My handloads were always moderate loads as a result. We built a rifle range on the property and I used to spend a lot of time at the bench developing the best loads. IMR powder always worked best in my guns for some reason.
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